S-Adenosyl-L-Methionine (SAMe) is a naturally occurring compound with significant physiological roles, including acting as a methyl donor in various biochemical processes. It is crucial in the synthesis of sulfur-containing compounds such as glutathione and cartilage components. SAMe has been widely used as a dietary supplement in Europe since 1975 and in the United States since 1999, marketed primarily for managing conditions like depression, osteoarthritis, fibromyalgia, liver disorders, and migraine headaches.

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Triphala is an ancient and revered Ayurvedic formula consisting of three fruits (amla, haritaki, and bahera).